Nitroreductase enzymatic substrates
US8211662B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | May 29, 2008 |
| Grant date | Jul 3, 2012 |
| Priority date | — |
| Expiry date | Jun 3, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/90209
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to an enzyme substrate for detecting nitroreductase activity of formula (I) below:in which X is S, NX1, O or NX1-CO; R1 is nothing or a substituent selected from Cl, CH3, Br, F, I, alkyl, aryl and carboxyl; R2 is nothing or a substituent selected from Cl, O—CH2—O, O—CH3, F, diethylenediamine-CH3, NR3R4, Br, I, alkyl, aryl, carboxyl, NO2 andR3 and R4 are independently H or an alkyl group containing from 1 to 4 carbon atoms; and X1 is selected from H, CH3, C2H4Ph, OH, alkyl and aryl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.