Patent · US Active

Sperm-specific cation channel, CATSPER1, and uses therefor

US8211666B2 · kind B2 · utility

0Cited by
6References
22Claims
0Family size

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Inventors

Key dates

Filing dateOct 30, 2003
Grant dateJul 3, 2012
Priority date—
Expiry dateJan 15, 2027

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA01K2267/03
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.