α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them

US8211859B2 · kind B2 · utility

Assignees

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• UNIVERSITE DE PARIS DESCARTES · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Didier Dubreuil · Juvisy-sur-Orge, FR
• Muriel Pipelier · Nantes, FR
• Laurent Micouin · Paris, FR
• Thomas Lecourt · Noisy-le-Sec, FR
• Vivien Lacone · Clichy, FR
• Marc Bonneville · Vertou, FR
• Jacques Lependu · Nantes, FR
• Anne-Laure Turcot-Dubois · Tarare, FR

Key dates

• Filing date: Oct 18, 2007
• Grant date: Jul 3, 2012
• Expiry date: Oct 31, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize α-galactoceramide analogs by a mere metathesis reaction. The α-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.