Patent · US Active

Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals

US8211885B2 · kind B2 · utility

0Cited by

2References

9Claims

0Family size

Assignee

Sanofi-Aventis · FR

Inventors

Henning Steinhagen · Pocking, DE
Bodo Scheiper · Frankfurt am Main, DE
Hans Matter · Langenselbold, DE
Hans Ulrich Stilz · Frankfurt am Main, DE
Gary MCCORT · Paris, FR

Key dates

Filing date	Jul 28, 2010
Grant date	Jul 3, 2012
Priority date	—
Expiry date	Jul 28, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to cyclic indole-3-carboxamides of the formula I,wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.