Capped pyrazinoylguanidine sodium channel blockers
US8211895B2 · kind B2 · utility
28Cited by
28References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 7, 2010 |
| Grant date | Jul 3, 2012 |
| Priority date | — |
| Expiry date | Sep 7, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application relates to pyrazinoyl guanidine sodium channel blockers having the structure:or a pharmaceutically acceptable salt thereof, where the structural variables are as defined herein. The present invention also relates pharmaceutical compositions comprising the sodium channel blockers and their use in methods of treatment, including the treatment of cardiovascular disease, cystic fibrosis, and chronic bronchitis and in the rehydration of mucosal surfaces and promotion of mucus clearance in a patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.