Antagonists of the transient receptor potential vanilloid 1 and uses thereof
US8211941B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 11, 2008 |
| Grant date | Jul 3, 2012 |
| Priority date | — |
| Expiry date | Apr 11, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/551
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
One of the major disabling symptoms of gastroparesis is nausea and vomiting which can be difficult to control with currently available treatments. It is postulated that signaling of gastrointestinal causes of nausea starts with activation of vagal afferent nerves that trigger the central emetic pathway. Most vagal afferent nerves are unmyelinated C-fibers, many of which express the vanilloid receptor TRPV1 and respond to capsaicin. Resiniferatoxin is a very potent capsaicin analogue that has a much more favorable ratio of desensitization to excitation than capsaicin leading to more effective desensitization without irritation. The present invention describes methods of alleviating acute or chronic nausea, vomiting by the administration of resiniferatoxin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.