Bifunctional fusion protein with thrombolytic and anticoagulant activities and uses thereof

US8212003B2 · kind B2 · utility

Assignee

• Institute of radiation medicine, academy of military medical sciences, PLA. · CN

Inventors

• Bingxing Shi · Beijing, CN
• Zuze Wu · Beijing, CN
• Aiping Yu · Beijing, CN
• Chunna Dong · Beijing, CN

Key dates

• Filing date: Sep 3, 2003
• Grant date: Jul 3, 2012
• Expiry date: Jun 13, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.