Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and thereof

US8212040B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Younes Bekkali · Danbury, US
• Rajashehar Betageri · Bethel, US
• Mario Cardozo · San Francisco, US
• Thomas A. Gilmore · Cambridge, US
• Christian Harcken · New Milford, US
• Thomas Martin Kirrane, Jr. · Danbury, US
• Daniel Kuzmich · Clovis, US
• John Proudfoot · Newtown, US
• Doris Riether · Biberach an der Riß, DE
• Hidenori Takahashi · Lagrangeville, US
• David Thomson · Ridgefield, US
• Ji Wang · Amherst, US
• Renee M. Zindell · New Milford, US
• Hossein Razavi · Danbury, US

Key dates

• Filing date: Apr 25, 2006
• Grant date: Jul 3, 2012
• Expiry date: Dec 14, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula (IA)wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.