Patent · US Active

Fluorescent photoprobe for the imaging of endothelin receptors

US8212058B2 · kind B2 · utility

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0References

7Claims

0Family size

Assignee

Universitätsklinikum Münster · DE

Inventors

Christoph Bremer · Hachenburg, DE
Carsten Höltke · Hachenburg, DE
Klaus Kopka · Dossenheim, DE
Michael Schäfers · Hachenburg, DE

Key dates

Filing date	Sep 6, 2006
Grant date	Jul 3, 2012
Priority date	—
Expiry date	Oct 18, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K49/0043
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a endothelin receptor antagonist conjugate of the formula (I) wherein R2 is an alkoxy group and one of R1 and R3 represents an alkoxy group and the other represents a group of the formula: (OCH2CH2)n—NH—X, wherein n is an integer of 1 to 100 and X represents a fluorescent dye and tautomers thereof. Furthermore, the present invention relates to a diagnostic composition comprising the compounds of the invention. The present invention also relates to the use of the compounds of the invention for the preparation of a diagnostic composition for the diagnosis of cancer, the evaluation of cancer biology and/or monitoring of anticancer therapy. In a further aspect, the present invention relates to kits comprising the compounds of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.