Patent · US Active

Transgenic mice for assessing drug metabolism and toxicity

US8212105B2 · kind B2 · utility

0Cited by

0References

10Claims

0Family size

Assignee

ITI Life Sciences · GB

Inventors

Charles Roland Wolf · Leyland, GB
Nico Scheer · Cologne, DE
Nicole Faust · Cologne, DE

Key dates

Filing date	May 26, 2010
Grant date	Jul 3, 2012
Priority date	—
Expiry date	May 26, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA01K2267/0393
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.