Anti-Aβ antibodies and their use

US8216577B2 · kind B2 · utility

Assignees

• F. Hoffmann-La Roche AG · CH
• MORPHOSYS AG · DE

Inventors

• Michael Bardroff · Soest, DE
• Bernd Bohrmann · Glückstadt, DE
• Manfred Brockhaus · Bettingen, CH
• Walter Huber · Kaiseraugst, CH
• Titus Kretzschmar · Steinhausen, CH
• Hansruedi Loetscher
• Corinna Löhning · Stockdorf, DE
• Christer Nordstedt · Gately Drive, SE
• Christine Rothe · Freising, DE

Key dates

• Filing date: Jul 28, 2009
• Grant date: Jul 10, 2012
• Expiry date: Sep 20, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.