Compositions and methods for detection and treatment of proliferative abnormalities associated with overexpression of human transketolase like-1 gene
US8216792B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Nov 10, 2009 |
| Grant date | Jul 10, 2012 |
| Priority date | — |
| Expiry date | May 22, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for in vitro diagnosis of carcinoma are disclosed. In one aspect the invention relates to methods such as detecting the level of transketolase like-1 polypeptide, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.