Detection of antibody that binds to water soluble polymer-modified polypeptides
US8216793B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 25, 2010 |
| Grant date | Jul 10, 2012 |
| Priority date | — |
| Expiry date | May 25, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6854
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.