Benzimidazole derivatives useful as TRP M8 receptor modulators
US8217060B2 · kind B2 · utility
1Cited by
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12Claims
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Key dates
| Filing date | May 4, 2010 |
| Grant date | Jul 10, 2012 |
| Priority date | — |
| Expiry date | Aug 7, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8 (transient receptor potential M8 channel). More particularly, the compounds of the present invention are useful in the treatment of inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold, anxiety and depression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.