Liquid phase peptide synthesis of KL-4 pulmonary surfactant
US8217142B2 · kind B2 · utility
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Key dates
| Filing date | Sep 30, 2008 |
| Grant date | Jul 10, 2012 |
| Priority date | — |
| Expiry date | Dec 7, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the α-carbon.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.