High affinity Melan-A T cell receptors
US8217144B2 · kind B2 · utility
6Cited by
0References
49Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 31, 2006 |
| Grant date | Jul 10, 2012 |
| Priority date | — |
| Expiry date | Nov 24, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides TCRs having an affinity (KD) of less than or equal to 3 μM, and/or an off-rate (koff) of 1×10−3 S−1 or slower, for the AAGIGILTV-HLA-A*0201 complex. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting cancer cells presenting that complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.