[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-flouro-1-(2-methoxy-ethyl)-4-trifluorom as an inhibitor of mast cell tryptase

US8217178B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Yong Mi Choi-Sledeski · Montgomery, US
• Nakyen Choy · Carmel, US
• Gregory Bernard Poli · Perkasie, US
• John J. Shay, Jr. · Bethlehem, US
• Patrick W. Shum · Holliston, US
• Adam W. Sledeski · Bound Brook, US

Key dates

• Filing date: Feb 16, 2011
• Grant date: Jul 10, 2012
• Expiry date: Feb 16, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to an indole benzylamine compound of formula I:useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient of a therapeutically effective amount of the compound, and to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier.