Patent · US Active

Single chain antibodies against β-amyloid peptide

US8221750B2 · kind B2 · utility

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0References

9Claims

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Assignee

Ramot at Tel-Aviv University Ltd. · IL

Inventors

Beka Solomon · Herzliya, IL
Rachel Cohen-Kupiec · Nes Ziona, IL

Key dates

Filing date	Jan 19, 2012
Grant date	Jul 17, 2012
Priority date	—
Expiry date	Jan 19, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/70
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Anti-AβP scFvs and single domain antibodies were generated, and when these antibodies were displayed on filamentous phage or as soluble protein molecules, stabilized by the maltose binding protein, they could prevent the fibrilization of Aβp 1-40 and disaggregate Aβp 1-40 fibrils generated in vitro. The anti-Aβp scFv antibodies also stained amyloid neuritic plaques on slices from transgenic mice. The anti-AβP scFv and single domain antibodies can be used for inhibiting or treating Alzheimer's disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.