Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
US8222009B2 · kind B2 · utility
1Cited by
6References
20Claims
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Key dates
| Filing date | Jun 17, 2010 |
| Grant date | Jul 17, 2012 |
| Priority date | — |
| Expiry date | Jun 30, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y102/02001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structureprepared by subjecting an acid of the structureto reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2with di-tert-butyl dicarbonate to form the BOC-protected amine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.