Modulation of gene expression through endogenous small RNA targeting of gene promoters
US8222221B2 · kind B2 · utility
88Cited by
5References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 3, 2009 |
| Grant date | Jul 17, 2012 |
| Priority date | — |
| Expiry date | Jan 27, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/50
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Gene expression can be selectively regulated by endogenous miRNAs that target promoters of genes. Altering of the activity of these promoter-targeting miRNAs with single-stranded complementary oligonucleotides that bind the miRNA causes modulation of expression of the target gene. Endogenous miRNAs that modulate expression of target genes can be identified by (a) evaluating an endogenous miRNA for complementarity to a target gene promoter; and (b) determining that the complementary miRNA modulates expression of the target gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.