Small molecule inhibitors of MDM2 and the uses thereof

US8222288B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Dongguang Qin · Auburn Hills, US
• Jianyong Chen · Tangxia, CN
• Shanghai Yu · Shanghai, CN

Key dates

• Filing date: Jun 14, 2010
• Grant date: Jul 17, 2012
• Expiry date: Sep 10, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/48
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).