Patent · US Active

Substituted N-phenyl-bipyrrolidine ureas and therapeutic use thereof

US8222290B2 · kind B2 · utility

8Cited by

1References

24Claims

0Family size

Assignee

Sanofi · FR

Inventors

Werngard Czechtizky · Frankfurt, DE
Zhongli Gao · Flemington, US
William Joseph Hurst · Oxford, US
Lothar Schwink · Stadtallendorf, DE
Siegfried Stengelin · Frankfurt am Main, DE

Key dates

Filing date	Mar 15, 2010
Grant date	Jul 17, 2012
Priority date	—
Expiry date	Feb 5, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine ureas of formula (I).Wherein R, R1, R2, R3, R4 and R5 are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl-bipyrrolidine ureas and intermediates therefor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.