Organosulfur prodrugs for the prevention and treatment of infectious diseases
US8222299B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 24, 2004 |
| Grant date | Jul 17, 2012 |
| Priority date | — |
| Expiry date | Jun 22, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/255
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for enhancing the overall beneficial immune system response in a host that works in conjunction with the host's natural immune system response to simultaneously enhance the host's ability to eliminate infectious microbes while suppressing the toxicity of the immune system response to the host. Allium related organosulfur compounds have a variety of antimicrobial and immunomodulatory properties that work together with the host's immune system in the prevention and treatment of disease. Prophylactic and therapeutic treatment is provided by administering an allium related organosulfur compound such that a localized thiosulfinate is caused to be formed in response to localized generation of reactive oxygen species such as hydrogen peroxide by the activated immune system cells. Allium related organosulfur compounds may be administered to the host in an efficient manner through the use of protein-bound S-AllylMercaptoCysteine or similar prodrugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.