Process for preparing macrocyclic compounds

US8222369B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Carl Alan Busacca · Poughkeepsie, US
• Fabrice Gallou · Danbury, US
• Nizar Haddad · Danbury, US
• Azad Hossain · Lindenhurst, US
• Suresh R. Kapadia · Danbury, US
• Jianxiu Liu · Richmond, US
• Chris Hugh Senanayake · Brookfield, US
• Xudong Wei · West Greenwich, US
• Nathan K. Yee · Seattle, US

Key dates

• Filing date: Sep 2, 2009
• Grant date: Jul 17, 2012
• Expiry date: Nov 17, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0812
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN:The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.