Surface active proteins as excipients in solid pharmaceutical formulations

US8226967B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Andreas Buthe · Steinfurt, DE
• Andreas Hafner · Gelterkinden, CH
• Franz Kaufmann · Glückstadt, DE
• Esther Gabor · Zwingenberg, DE
• Guido Meurer · Seeheim-Jugenheim, DE
• Jürgen Eck · Bensheim, DE
• Gordon Bradley · Brampton, CA

Key dates

• Filing date: Nov 13, 2009
• Grant date: Jul 24, 2012
• Expiry date: Nov 13, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/37
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.