Inhalable powders comprising protein, phenylalanine, and other protein stabilizers

US8226982B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Torsten Schultz-Fademrecht · Maselheim, DE
• Patrick Garidel · Norderstedt, DE
• Beate Fischer · Bad Waldsee, DE
• Karoline Bechtold-Peters · Biberach, DE

Key dates

• Filing date: Jun 22, 2007
• Grant date: Jul 24, 2012
• Expiry date: Aug 28, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention therefore relates to protein-containing powders, wherein the proportion of phenylalanine is at least 30% (w/w), or at least 40% (w/w). It has been shown that phenylalanine-containing powders, particularly after spray drying, are very suitable in terms of their aerodynamic characteristics and protein stabilization for preparing powders or protein compositions with improved aerodynamic properties. The main component is phenylalanine and the optional further component is an excipient which has good water-solubility compared with phenylalanine, preferably a sugar or a polyol.