Process for the enantioselective reduction and oxidation, respectively, of steroids

US8227208B2 · kind B2 · utility

Assignee

• IEP GMBH · US

Inventors

• Antje Gupta · Wiesbaden, DE
• Anke Tschentscher · Eltville am Rhein, DE
• Maria Bobkova · Idstein, DE

Key dates

• Filing date: Apr 11, 2007
• Grant date: Jul 24, 2012
• Expiry date: Jun 13, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/002
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for the enantioselective reduction of compounds having a steroid structure (ABCD) including one or several heteroatoms, one or several double bonds and/or aromatic components in the ring structure and having at least one oxo group at positions 3, 7, 11, 12 or 17 in the steroid ring system or in the a-position of any carbon moiety of the steroid structure:comprising providing the oxosteroid compound in the reaction at a concentration of ≧50 g/L, a reduced cofactor NADH or NADPH, a hydroxysteroid dehydrogenase and a secondary alcohol or cycloalknaol to effect the enantioselective reduction.