Patent · US Active

Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation

US8227450B2 · kind B2 · utility

2Cited by

23References

21Claims

0Family size

Assignee

Ambrilia Biopharma, Inc. · CA

Inventors

Guy Milot · Chapel Hill, US
Stephane Branchaud · Montréal, CA
Brent Richard Stranix · Rue du Bois des Loges, CA

Key dates

Filing date	Nov 30, 2006
Grant date	Jul 24, 2012
Priority date	—
Expiry date	Mar 28, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F9/091
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides processes for synthesizing lysine based compounds of the formula;wherein R1 may be, for example, (HO)2P(O)—, (NaO)2P(O)—, wherein X may be, for example, NH2, Y may be H, F, Cl, or Br, and wherein n, X′, Y′, R2, R3, R4, R5 and R6 are as defined herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.