Estrogenic compounds, pharmaceutical compositions and formulations comprising the same
US8227454B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 23, 2011 |
| Grant date | Jul 24, 2012 |
| Priority date | — |
| Expiry date | Jun 23, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J17/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel estrogenic compounds of Formula I are provided.wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, R1 is selected from the group consisting of hydrogen, sulfate and glucoronate or other esters, and when the wavy line is a double bond, R1 does not exist; R2 is lower alkyl; R3 may be selected from the group consisting of hydrogen, sulfate, or glucuronide or other esters; and R4 through R13 may independently be selected from the group consisting of hydrogen, hydroxy, ketone, lower alkyl, lower alkoxy, halogen, and carbonyl groups and R14 is selected from the group consisting of hydrogen, sulfate and glucoronide and other esters. When R1 is hydroxy, the hydroxy or ester substituent may have either an α or a β orientation. Compositions of matter including compounds of the present invention are also provided as are methods of treating mammals in need of treatment using compounds of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.