Patent · US Active

2,4-disubsituted thiazoles and pharmaceutical compositions thereof

US8227495B2 · kind B2 · utility

10Cited by

4References

18Claims

0Family size

Assignee

Metabolex, Inc. · US

Inventors

Xin Chen · Lexington, US
Peng Cheng · Tianjin, CN
L. Edward Clemens · Davis, US
Jeffrey D. Johnson · Moraga, US
Jingyuan Ma · Sunnyvale, US
Alison Murphy · Milpitas, US
Imad Nashashibi · San Jose, US
Christopher J. Rabbat · San Jose, US
Jiangao Song · Cupertino, US
Maria E. Wilson · San Francisco, US
Yan Zhu · Beijing, CN
Zuchun Zhao · El Sobrante, US

Key dates

Filing date	Aug 14, 2009
Grant date	Jul 24, 2012
Priority date	—
Expiry date	Nov 27, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.