Compounds as histone deacetylase inhibitors

US8227516B2 · kind B2 · utility

Assignee

• 4SC DISCOVERY GMBH · DE

Inventors

• Alexander B. Maurer · Bad Homburg vor der Höhe, DE
• Sascha Hoevelmann · Frankfurt am Main, DE
• Elke Martin · Karlsruhe, DE
• Bernd Hentsch · Frankfurt am Main, DE
• Michael Gassen · Munich, DE
• Juergen Kraus · Andechs, DE
• Rolf Krauss · Gräfelfing, DE
• Adam VINCEK · Gainesville, US

Key dates

• Filing date: Jul 16, 2007
• Grant date: Jul 24, 2012
• Expiry date: Jan 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.