Process for preparing creatine, creatine monohydrate or guanidinoacetic acid

US8227638B2 · kind B2 · utility

Assignee

• Alzchem Trostberg GmbH · DE

Inventors

• Franz Thalhammer · Trostberg, DE
• Thomas Gastner · Trostberg, DE

Key dates

• Filing date: Apr 5, 2007
• Grant date: Jul 24, 2012
• Expiry date: Nov 11, 2028

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01D61/422
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A process for producing creatine, creatine monohydrate or guanidinoacetic acid is proposed, wherein firstly N-methylethanolamine or ethanolamine is catalytically dehydrogenated in each case in alkaline solution and the sarcosinate or glycinate solutions that are obtained in this manner are finally reacted under acidic conditions with a guanylating agent such as for example O-alkylisourea or cyanamide. In this manner products are obtained in high yields and very good purity where in contrast to the prior art no traces whatsoever of hydrocyanic acid, formaldehyde, chloroacetic acid or ammonia are present. The formation of the toxicologically critical dihydrotriazine is also avoided.