Patent · US Active

N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

US8227639B2 · kind B2 · utility

34Cited by

10References

21Claims

0Family size

Assignees

Cardioxyl Pharmaceuticals, Inc. · US
THE JOHNS HOPKINS UNIVERSITY · US

Inventors

John P. Toscano · Glen Arm, US
Frederick Arthur Brookfield · Woodstock, GB
Andrew D. Cohen · Mamaroneck, US
Stephen Martin Courtney · Woodstock, GB
Lisa Marie Frost · Abingdon, GB
Vincent Jacob Kalish · Annapolis, US

Key dates

Filing date	Sep 26, 2008
Grant date	Jul 24, 2012
Priority date	—
Expiry date	Jan 6, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D333/38
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.