Method and device for examining the attachment or detachment of living or dead cells or cell-like particles or other surface accumulations on surfaces by means of plasmon resonance and use of said method and said device

US8232061B2 · kind B2 · utility

Assignee

• Andreas Hofmann · DE

Inventors

• Andreas Hofmann · North Bend, US
• Norbert Danz · Jena, DE
• Silke Hofmann · Wallenfels, DE
• Michael Keusgen · Marburg, DE
• Ulla Magdolen · Tauberbischofsheim, DE

Key dates

• Filing date: Feb 1, 2008
• Grant date: Jul 31, 2012
• Expiry date: Jun 4, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N21/553
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for examining an attachment or detachment of living cells, dead cells or cell-like particles on a surface using plasmon resonance includes irradiating a measurement region with beams over the entire angle of incidence spectrum and capturing, combining and evaluating beams with identical angles of incidence reflected from different points of the measurement region with a determination of the angle of light incidence with a lowest reflected light intensity and measuring an angle of incidence shift of an intensity minimum that occurs. The evaluating includes registering different angles of incidence of two or more intensity minima occurring simultaneously to reflect a respective level of the surface accumulations.