Compounds for delivery of therapeutic and imaging moieties to nerve cells
US8232251B2 · kind B2 · utility
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19References
28Claims
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Key dates
| Filing date | Nov 25, 2008 |
| Grant date | Jul 31, 2012 |
| Priority date | — |
| Expiry date | Nov 25, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention features compounds of the general formula:B-L-Mwhere B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.