Patent · US Active

Process for preparing temozolomide

US8232392B2 · kind B2 · utility

2Cited by

4References

31Claims

0Family size

Assignee

CHEMI S.P.A. · IT

Inventors

Stefano Turchetta · Roma, IT
Lorenzo De Ferra · Patrica, IT
Maurizio Zenoni · Paullo, IT
Mauro Anibaldi · Patrica, IT

Key dates

Filing date	Jul 30, 2009
Grant date	Jul 31, 2012
Priority date	—
Expiry date	Jul 28, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Described is a new process for producing temozolomide, comprising the reaction between 5-aminoimidazole-4-carboxamide and N-succinimidyl-N′-methyl carbamate and the subsequent reaction of the thus obtained carbamoyl 5-aminoimidazole-4-carboxamide with sodium nitrite. Temozolomide is then purified by chromatography on adsorbent polymeric resin and subsequent crystallization from water and acetone.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.