Crystalline 1-(3-fluorophenyl)-5-methyl-2-(1H)pyridone, the preparation methods, compositions and applications thereof

US8232408B2 · kind B2 · utility

Assignee

• SUNSHINE LAKE PHARMA CO., LTD. · CN

Inventors

• Jiamei Chen · Nantong, CN
• Tongbu Lu · Dongguan, CN
• Song Chen · Nanhu, CN
• Jinghui Cai · Dongguan, CN
• Zhaolin Fu · Dongguan, CN
• Zhe He · Beijing, CN
• Xuefeng Wang · Lo Wu, CN
• Chaozhi Wang · Dongguan, CN
• Yonge Liu · Dongguan, CN
• Lijian Tao · Changsha, CN
• Gaoyun Hu · Dongguan, CN

Key dates

• Filing date: Mar 10, 2009
• Grant date: Jul 31, 2012
• Expiry date: Jul 15, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Crystalline pyridone compound, which is the white needle crystal containing no water and other crystallization solvents. Its unit cell belongs to monoclinic system and has space group of P21/n, wherein a=3.8512(2), b=20.2535(12), c=12.1628(6) Å, β=92.850(5)° and crystal cell volume V=947.53(9) Å3. Pyridone compound crystal of this form has the needed properties for preparing or making treatment compositions in large scale. It can be used for treating organs fibrosis of liver, kidney, lung and etc. and reducing skin scars.