Composition comprising cross-species-specific antibodies and uses thereof

US8236308B2 · kind B2 · utility

Assignee

• Micromet AG · DE

Inventors

• Roman Kischel · Munich, DE
• Tobias Raum · Munich, DE
• Bernd Schlereth · Germering, DE
• Doris Rau · Munich, DE
• Ronny Cierpka · Munich, DE
• Peter Kufer · Munich, DE

Key dates

• Filing date: Oct 10, 2006
• Grant date: Aug 7, 2012
• Expiry date: Feb 13, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/622
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to uses of bispecific antibodies exhibiting cross-species specificity for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of the same in non-human species and humans. The present invention moreover relates to methods for evaluating the in vivo safety and/or activity and/or pharmacokinetic profile of said bispecific anti-bodies exhibiting cross-species specificity. The present invention also relates to methods of measuring the biological activity and/or efficacy of such bispecific antibodies exhibiting cross-species specificity. In addition, the present invention relates to pharmaceutical compositions comprising bispecific single chain antibodies exhibiting cross-species specificity and to methods for the preparation of pharmaceutical compositions comprising said bispecific single chain antibodies exhibiting cross-species specificity for the treatment of diseases.