Method of screening for therapeutic compounds for vascular disorders and hypertension based on URAT1 activity modulation
US8236488B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 11, 2004 |
| Grant date | Aug 7, 2012 |
| Priority date | — |
| Expiry date | Apr 1, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/103332
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
It is intended to clarify a transportation system participating in the uric acid uptake in vascular smooth muscle cells (VSMCs) and provide a novel remedy, a preventive or a treating agent for vascular disorders, hypertension and renal disorders with the use of a drug participating in this transportation system. It is also intended to provide a novel screening system for a remedy, a preventive or a treating agent for vascular disorders, hypertension and renal disorders with the use of such a transportation system. Namely, a medicinal composition for healing, preventing or treating vascular disorders, hypertension and renal disorders which comprises a drug having an effect of inhibiting the uric acid uptake by a uric acid transporter URAT1 and a pharmaceutically acceptable carrier; and a method of screening a substance efficacious for healing, preventing or treating vascular disorders, hypertension and renal disorders which comprises using a cell line expressing URAT1 in the presence or absence of a test compound and assaying the uric acid uptake level, cell proliferation ability or the amount of a monocyte chemotactic factor produced by the cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.