Methods of and compositions for inhibiting the proliferation of mammalian cells

US8236543B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Levava Roiz · Givat Shmuel, IL
• Betty Schwartz · Rehovot, IL
• Patricia Smirnoff · Rehovot, IL
• Oded Shoseyov · Karmei Yosef, IL

Key dates

• Filing date: Sep 27, 2010
• Grant date: Aug 7, 2012
• Expiry date: Dec 4, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.