Patent · US Active

Modified animal lacking functional PYY gene, monoclonal antibodies that bind PYY isoforms and uses therefor

US8236933B2 · kind B2 · utility

0Cited by

1References

19Claims

0Family size

Assignee

Garvan Institute of Medical Research · AU

Inventors

Herbert Herzog · Sydney, AU
Charles Mackay · Sydney, AU

Key dates

Filing date	Apr 13, 2006
Grant date	Aug 7, 2012
Priority date	—
Expiry date	Sep 23, 2028

Classification

Technology area (CPC A)Human Necessities
CPC primaryA01K2267/03
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides transgenic animals having a reduced level of expression of peptide YY (PYY) and drug screening platforms using the transgenic animals for identifying agonists and antagonists of PYY. The present invention further provides monoclonal antibodies that bind specifically to full-length PYY[1-36] or the processed form thereof i.e., PYY[3-36] and to diagnostic and drug screening platforms using the monoclonal antibodies. The invention has particular utility for the diagnosis of a predisposition or risk of a subject becoming obese, developing one or more pathologies associated with obesity, or developing a disease/disorder of bone tissue.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.