Processes for highly enantio- and diastereoselective synthesis of acyclic epoxy alcohols and allylic epoxy alcohols
US8236976B2 · kind B2 · utility
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1References
13Claims
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Key dates
| Filing date | Mar 9, 2005 |
| Grant date | Aug 7, 2012 |
| Priority date | — |
| Expiry date | Jan 2, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D301/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The inventive subject matter relates to novel processes for making an epoxy alcohol from an aldehyde, comprising the steps of: (a) adding (i) an organozinc compound or (ii) divinylzinc compound and an diorganozinc compound to said aldehyde in the presence of a first catalyst to form an allylic alkoxide compound; and (b) epoxidizing said allylic alkoxide compound in the presence of an oxidant and a second catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.