Method for detecting rheumatoid arthritis-specific autoantibodies
US8241856B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 2002 |
| Grant date | Aug 14, 2012 |
| Priority date | — |
| Expiry date | Feb 6, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/564
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for detecting anti-filaggrin-autoantibodies specific to rheumatoid arthritis in a biological sample, by providing a filaggrin with no citrulline residues (FNC) having an arginine residue or a filaggrin peptide with no citrulline residues (PFNC) having an arginine residue. Also provided are a citrulline-containing filaggrin (FC) having the peptide sequence of the FNC where some arginine residues have been converted to citrulline residues or a citrulline-containing peptide (PFC) having the peptide sequence of the PFNC, where at least one arginine residue has been converted to a citrulline residue. The sample is contacted with the FNC or PFNC and the FC or PFC, and the resulting immune complexes are detected and quantified, with a value XNC and XC, respectively. Anti-filaggrin-autoantibodies specific to rheumatoid arthritis are determined to be present in the biological sample if the value of XC is greater than the value of XNC.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.