Diazepane-acetamide derivatives as selective 11β-HSD1 inhibitors
US8242107B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Oct 5, 2007 |
| Grant date | Aug 14, 2012 |
| Priority date | — |
| Expiry date | Dec 24, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to diazepane-acetamide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.