Patent · US Active

Combination of a NSAID and a PDE-4 inhibitor

US8242146B2 · kind B2 · utility

0Cited by

3References

4Claims

0Family size

Assignee

NYCOMED GMBH · DE

Inventors

Thomas KLEIN · Radolfzell, DE
Hans-Peter Kley · Allensbach, DE

Key dates

Filing date	Dec 20, 2007
Grant date	Aug 14, 2012
Priority date	—
Expiry date	Apr 10, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to the combined use of a PDE4 inhibitor and a conventional NSAID in the treatment of an inflammatory disease and/or an inflammation-associated disorder while minimizing gastrointestinal side effects, such as gastric erosions and ulcer, which are frequently associated with the use of conventional NSAIDs. A preferred PDE 4 inhibitor for this combination is roflumilast or a derivative thereof. A preferred conventional NSAID for this combination is diclofenac or a derivative thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.