Method for reducing the weight of a subject or inhibiting weight gain in a subject

US8242171B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• The General Hospital Corporation · US

Inventors

• David A. Sinclair · Feldkirchen-Westerham, DE
• Maria Alexander-Bridges · Newton, US

Key dates

• Filing date: Jan 7, 2010
• Grant date: Aug 14, 2012
• Expiry date: Jan 7, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.