Protecting groups for RNA synthesis
US8242258B2 · kind B2 · utility
105Cited by
15References
20Claims
0Family size
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Key dates
| Filing date | Dec 3, 2007 |
| Grant date | Aug 14, 2012 |
| Priority date | — |
| Expiry date | Apr 6, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with orthoester-type protecting groups. The 2′ protected monomers also include a second, aryl carbonate-type, protecting group. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.