Non-radioactive traceable metal isotope-enriched nanoparticles and method of their use for determining biodistribution
US8246932B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Mar 28, 2008 |
| Grant date | Aug 21, 2012 |
| Priority date | — |
| Expiry date | May 15, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2993
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.