Dendritic cell-associated lectin-like molecules, compositions and methods of use
US8246959B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 5, 2007 |
| Grant date | Aug 21, 2012 |
| Priority date | — |
| Expiry date | Jan 5, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/5154
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel dendritic cell-associated lectin-like (DCAL-1) molecules, compositions and therapeutic methods of use. In one aspect, the invention provides isolated nucleic acid molecules that are capable of remaining hybridized to SEQ ID NO:1 or SEQ ID NO:3, including nucleic acid molecules that encode DCAL-1 polypeptides. In another aspect, the invention provides DCAL-1 polypeptides and portions thereof which are useful to stimulate T cell proliferation. In another aspect, the invention provides antibodies that specifically bind to DCAL-1 which are useful for promoting maturation of dendritic cells and for stimulating an immune response in vivo. In another aspect the invention provides methods of stimulating an immune response in an animal comprising introducing into the animal an anti-DCAL-1 antibody of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.