Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells

US8246995B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Hongjie Dai · Sunnyvale, US
• Nadine Wong Shi Kam · Stanford, US
• Paul A. Wender · Menlo Park, US
• Zhuang LIU · Longbeilingcun, CN

Key dates

• Filing date: May 9, 2006
• Grant date: Aug 21, 2012
• Expiry date: Sep 7, 2030

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes and wires, functionalized with a linking group that is covalently bound to the nanotubes, or, alternatively, to the biologically active molecule, such as a protein. The biologically active molecule is preferably released from the nanotube when the complex has been taken up in an endosome.